Article Abstract:
The most common genetic forms of dwarfism in humans includes achondroplasia, hypochondroplasia and thanatophoric dysplasia types I and II (TDI and TDII) caused by different mutations in a fibroblast growth-factor receptor FGFR3. A study showed that mutant TDII FGFR3 has a constitutive tyrosine kinase activity that can specifically activate the transcription factor Stat1. It was also shown that TDII FGFR3 may use Stat1 as a mediator of growth retardation in bone development, as expression of TDII FGFR3 induced nuclear translocation of Stat1, expression of the cell-cycle inhibitor p21 (supra WAF1/CIP1), and growth arrest of the cell.
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Article Abstract:
P- and E-selectins are both essential for the recruitment of T-helper-1 (Th1) but not T-helper-2 (Th2) into a cutaneous inflammation. Experiment results using P- and E-selectin immunoglobulin construct stains show positive reactions for Th1 cells while Th2 cells were unreactive. These demonstrate the specific effector functions and distinct migration behavior of Th1 cells. The recruitment mediation function of endothelial selectins provide an additional level of regulation for both effector function profile and character of local immune response.
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Article Abstract:
An affinity probe, an antibody form of mouse E-selectin, helps isolate the major ligand of E-selectin (ESL-1). ESL-1 is a 150 K glycoprotein that resembles a fibroblast growth factor receptor from chicken, exclusive of a 76-amino acid residue present in the amino terminal domain of ESL-1. ESL-1 mediates cell adhesion of E-selectin, and the presence of ESL-1 antibodies hinders the interaction between E-selectin and mouse myeloid cells.
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