Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

Article Abstract:

It has been established that D2 receptors in the nucleus accumbens could be involved in the modulation of physical opiate dependence. However, they are not needed to bring about a complete manifestation of the somatic signs of opiate withdrawal. Local administration of an opiate agonist into the nucleus accumbens did not bring about any behavioural sign of withdrawal in morphine-dependent rats. There is a dissociation between the mechanisms involved in the rewarding properties of opiates and the somatic signs of the naloxene-precipitated withdrawal syndrome.

author: Roques, Bernard P., Borrelli, Emiliana, Samad, Tarek A., Maldonado, Rafael, Saiardi, Adolfo, Valverde, Olga
Research

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Dissociation of the neural correlates of implicit and explicit memory

Article Abstract:

Neural activity elicited by recently experienced words that are not consciously recognized is different from activity prompted by genuinely new words, according to research using scalp-recorded event-related brain potentials to identify neural activity linked with implicit and explicit memory. It was shown that old words in a recognition memory test can produce three different patterns of memory-related activity. This research is the first indication that the neural correlates of implicit and explicit memory can be dissociated within a single task.

author: Schloerscheidt, Astrid M., Rugg, Michael D., Mark, Ruth E., Walla, Peter, Birch, Claire S., Allan, Kevin

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Is dopamine a missing link?

Article Abstract:

Research indicates that besides the D1 dopamine receptor, which is linked to working memory, prefrontal cortex, dopamine and neuropsychiatric disorders, there could be other links to regulate memory. Treatments for neuropsychiatric disorders involve receptors other than the D1 receptor, including serotonin and D2, indicating that the D1 receptor is only one factor in a complex system rather than working in isolation as previously believed.

author: Desimone, Robert

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subjects list: Dopamine receptors, Physiological aspects, Memory
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