Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus

Article Abstract:

A study was conducted to demonstrate that the 1918 virus caused a highly pathogenic respiratory infection in cynomolgus macaque model that culminated in acute respiratory distress and a fatal outcome. The infected animals mounted an immune response characterized by dysregulation of the antiviral response that was insufficient for protection.

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Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor

Article Abstract:

A study on the brain-derived neurotrophic factor (BDNF) is carried out. The study reports that in cultured cerebellar granule cells, TRPC channels contribute to the brain-derived neurotrophic factor (BDNF)-induced elevation of Ca(super 2+) at the growth cone and are required for BDNF-induced chemo-attractive turnings.

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Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones

Article Abstract:

The existence of transient receptor potential (TRP)-like channel activity is reported in the growth cones of cultured Xenopus neurons. This activity can be modulated by exposure to nextrin-1 and brain-derived neurotrophic factor that are two chemoattractants for axon guidance.

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