Article Abstract:
An intrinsic circadian rhythm regulates the activity of a long open time (I(sub LOT)) cationic channel contained in cultured pineal cells of chicken. I(sub LOT) is a Ca2+ permeable channel and is active only during the night. Polarization affects the amplitude of the channel's current but has no effect on its opening. The kinetics of the channels are fitted by a sum of three exponential factors. The activity of I(sub LOT) is unaffected by short light pulses and the presence of cyclic nucleotides.
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Article Abstract:
Research studies have located areas of the CIC isoform human skeletal muscle that contribute to anion-selective conduction pathway formation. An accessibility barrier between external and internal milieu is spanned by the CIC channel pore's core structural element, with the GKxGPxxH evolutionarily conserved sequence motif identified. Isoform-specific differences in anion selectivity are partly due to neighbouring fifth and third transmembrane segment sequences.
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Article Abstract:
Research indicates that the Torpedo CIC-0 family chloride channel contains two aqueous permeation pathways, also described as pores. The human CIC-1 (hCIC-1) isoform, like many other ion channels investigated, has just one pore. Heterodimeric and homodimeric cysteine-substituted channel configurations are illustrated. Experiments using site-specific mutagenesis transient transfection and heterodimeric tandem construction on tsA201 cells are described.
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