Article Abstract:
Cell survival control is important in animal development and in diseases such as cancer. Phosphoinositide 3-kinase (P13K), along with its serine/threonine protein kinase AKt, have been implicated in a route conveying survival signals from cell-surface receptors. A missing piece in the pathway is the dissociation of Bad, a protein promoting cell death, from Bcl-xL, a cell survival factor. Akt has been identified as the kinase that phosphorylates Bad on the site needed for its interaction with 14-3-3.
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Article Abstract:
A study has been conducted to examine the role of protein coat auxilin in uncoating clathrin-coated vesicles that transport selected membrane proteins from the clel surface to the endosomal system. The results showed that auxilin binds with high affinity to clathrin lattices to catalyze protein folding and protein transport across the cell membrane. Auxilin has also been shown to catalyze the selective disruption of protein-protein interactions.
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Article Abstract:
Chemokines were originally defined as host defence proteins, but also have other functions, with chemokine receptors such as CXCR4, important in the pathogenesis of HIV-1. Tachibana and colleagues and Zou and colleagues have reported that CXCR4 deletion is embryologically lethal in mice. This expands the biological significance of chemokines to a wider biological role than was first thought.
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