Article Abstract:
Chemokines are implicated in the inflammatory reactions of the body by regulating selective recruitment and activation of leukocytes in acute and chronic inflammatory diseases. The activities of the chemokines are regulated by the G protein-coupled, seven transmembrane receptors. Cloning has been done on seven chemokine receptors, erythrocyte Duffy antigen receptor and two virally encoded chemokine receptors. The presence of chemokines in inflammatory processes may suggest a guide for the design of therapeutic interventions aimed at controlling inflammatory responses.
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Article Abstract:
A study of the H1 histamine receptor using molecular cloning of bovine adrenal medulla showed the differences between H1 and H2 histamine receptors. Although the homology of the two receptors are highly similar, the intracellular loop of the H1 receptor is longer, suggesting its function in phosphoinositide metabolism. The H1 receptors also have threonine and asparagine residues, respectively, and are also found in H1 receptors instead of threonine and aspartate, which are typical in H2 receptors.
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Article Abstract:
The cloning of prostanoid receptors of prostaglandins and thromboxanes have been recorded raising important issues on the diversity, distribution and physiological roles of these receptors. The use of homology based screening may result in the discovery of additional putative subtypes. The cloning of prostanoid receptor genes is expected to benefit genetic manipulations in the future.
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