Article Abstract:
The subfamily of 5-hydroxytryptamine(sub 1D) (5-HT1D) receptor system exhibits similarities and differences among related subgroup elements. Alpha 5-HT1D, beta 5-HT1D and 5-HT1B are three clones of the 5-HT1D subgroup which feature different functional mechanisms and pharmacological interactions. Alteration of amino acid sequencing of hydroxytryptamine receptor homologues can greatly affect pharmacological binding similarity. The present inability to distinguish the action of alpha and beta 5-HT1D prevents determination of their respective roles in neuropharmacology.
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Article Abstract:
The results from the neurogenic inflammation and c-fos expression studies have confirmed the neural transmission blockade mechanism of both sumatriptan and ergot alkaloids in relieving vascular headaches. The mitigating mechanism involves the mediation of a prejunctional 5-hydroxytryptamine-like receptor which constricts coronary artery and intra-cranial vascular smooth muscle. Furthermore, the neuronal mechanism of sumatriptan and ergot alkaloids makes them viable medications for migraines complicating meningeal inflammation.
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Article Abstract:
Pharmacological studies reveal that the application of molecular cloning techniques yielded a diverse set of neurotransmitter receptors which exhibit the capacity for exploitation in the area of selective drug development. These findings are best illustrated by the cloning of 5-HT (serotonin) receptors. Other studies validate these results but indicate biphasic curve solutions to displacement studies.
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