Article Abstract:
A classification scheme for sigma binding sites is proposed based on data from biochemical and ligand-binding experiments. Important ligands used in distinguishing sigma subtypes include pentazocine and SK&F10047 which are specific for sigma 1 sites. Carbetapentane, dextromethorphan and phenytoin are sigma 1 selective ligands. Although haloperidol and DTG are the most used sigma ligands, they can not discriminate between sigma 1 and 2 receptors. Despite several biological functions attributed to sigma binding sites, specific functional roles of sigma 1 and 2 are unclear.
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Article Abstract:
The role of central nervous system (CNS) chemokines and chemokine receptors in neuroinflammation and patterning has been reviewed. Chemokines are small proteins from 8 to 10 kDa involved in inflammatory-cell recruitment in the immune system. Chemokines and their receptors in the CNS are expressed at low levels in astrocytes, microglia and neurons. Their physiological function are facilitated by G protein-coupled receptors of the seven transmembrane domain, rhodopsin-type superfamily and have two main sites of interaction with their receptors.
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Article Abstract:
Dehydroepiandrosterone (DHEA) cannot yet be classified as a 'superhormone' until its physiological significance and therapeutic use are established. The long-term prophylactic and therapeutic applications of DHEA must still be validated by clinical trials in large samples of aging individuals and in various age-related pathologies. Although it has been confirmed that serum levels of DHEAs decrease with age, there is yet no definitive evidence of a direct relationship between such declines and age-associated disorders in the elderly.
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