Vav3 regulates osteoclast function and bone mass
Article Abstract:
Vav3, a Rho family guanine nucleotide exchange factor, is identified as an essential factor for stimulated osteoclast activation and bone density in vivo. The genetic and biochemical evidence is provided for the role of Syk tyrosine kinase as a crucial upstream regulator of Vav3 in osteoclasts stating that Vav3 could be considered as a new target for antiosteoporosis therapy.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Retinaldehyde represses adipogenesis and diet-induced obesity
Article Abstract:
A study showed that retinaldehyde present in rodent fat has a capability to inhibit adipogenesis and suppress peroxisome proliferator-activated receptor-[gamma] and retinoid X receptor (RXR) responses by binging to retinol-binding proteins (CRBP1, RBP4).
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Futility and avoidance: medical professionals in the treatment of obesity. A 33-Year-Old Woman With Morbid Obesity
- Abstracts: Respiratory function in severe gestational proteinuric hypertension: the effects of rapid volume expansion and subsequent vasodilatation with verapamil
- Abstracts: Changing perceptions. Pressure-sore awareness in hospital. Heel pressure ulcers: the extent of the problem
- Abstracts: Relationship of blood pressure, heart rate and behavioral mood state to norepinephrine kinetics in younger and older men following caffeine ingestion
- Abstracts: The latent nuclear antigen of kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells