The role of early HIV infection in the spread of HIV through populations

Article Abstract:

Reducing the contagiousness of people infected with HIV during the early stages of the infection could more effectively contain the epidemic than doing so in the later stages. Most models of the spread of HIV in a population have focused on the probability that an individual will transmit the virus but have not accounted for changes in sexual partnerships. When this is taken into account, those who are in the early stages of the disease are the most contagious individuals and this is true both early and late in the course of the epidemic.

Author: Lange, Kenneth, Foxman, Betsy, Pollock, Stephen M., Simon, Carl P., Koopman, James S., Jacquez, John A., Welch, Gavin W., Barth-Jones, Daniel, Adams, Andrew L.
HIV (Viruses), HIV

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Mother-to-child transmission of HIV-1

Article Abstract:

The author has developed a system to predict probability of transfer of HIV infection from mother to child which depends on the degree of the infection in the mother. The probability is connected to the amount of viral load the mother has, and can be used during pregnancy or postnatally during breast-feeding.

Author: Jacquez, John A.
Statistical Data Included, Maternal-fetal exchange

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Mutation takes no vacation: can structured treatment interruptions increase the risk of drug-resistant HIV-1?

Article Abstract:

Structured treatment interruptions may increase the growth of HIV variants that are resistant to AIDS drugs, according to a model developed by researchers. Structured treatment interruptions have been proposed as a means of stimulating the immune system but it could have unintended consequences.

Author: Dorman, Karin S., Kaplan, Andrew H., Lange, Kenneth, Sinsheimer, Janet S.
Drug resistance in microorganisms, Microbial drug resistance

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Subjects list: Models, HIV infection, HIV infections, Disease transmission
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