The heart of genomics

Article Abstract:

Issues related to the genetic aspects of cardiac diseases are examined, focusing on how information supplied from the human genome project may affect the course of cardiac disease research. Topics include the socioeconomic consequence of cardiac diseases; the role genomics may play in specific cardiac diseases such as hypertrophic cardiomyopathy; and scientific challenges for patient genotyping.

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The total artificial heart

Article Abstract:

This article presents the recent advances in the field of total artificial heart designing and construction and its use in the artificaial heart transplantation procedures. The first total artificial heart, the Liotta, fabricated in 1969 is followed by the Akutsu in 1981 and Jarvik-7 five years later. The latest versions are the AbioCor and the Sarns with the former being currently evaluated.

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Histidine button engineered into cardiac troponin I protects the ischemic and failing heart

Article Abstract:

The substitution of a single histidine residue present in the fetal cardiac Tnl isoform into the adult cardiac Tnl isoform at codon 164 results in the enhancement of cardiac performance in vitro and in vivo. Systolic and diastolic function is improved and reperfusion-associated ventricular arrhythmias are mitigated by the histine-modified Tnl in the isolated heart.

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