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Down regulation by iron of prostaglandin E2 production by human synovial fibroblasts

Article Abstract:

Iron appears to impede prostaglandin E2 (PGE2) production in synovial tissue, an important regulator of inflammation and damage in the arthritic joint. Researchers incubated synovial tissue samples from arthritis patient in solutions containing iron or a physiologically neutral medium. Synovial fibroblast tissue in iron citrate produced less PGE2 than fibroblasts in the neutral solution. PGE2 production increased when an iron-binding agent was added to the iron citrate solution. Inhibition of PGE2 production could reduce the inflammation of arthritis.

Japan, Physiological aspects, Iron in the body, Iron (Nutrient), Arthritis, Synovial membranes, Synovial membrane, Prostaglandins E

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Hydroxychloroquine and visual screening in a rheumatology outpatient clinic

Article Abstract:

Evidence does not suggest the need for twice yearly comprehensive eye examinations for patients treated with low-dose hydroxychloroquine who have no evidence of eye abnormalities before treatment begins. Eye health was evaluated before hydroxychloroquine treatment was begun and twice yearly thereafter among 758 patients treated for various connective tissue disorders. The eye abnormalities found in only 12 of these patients were attributed to causes other than the drug treatment. No patients had damage to the retina.

Complications and side effects, Medical examination, Drug therapy, Eye, Connective tissue diseases, Eye examination, Hydroxychloroquine

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