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Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas

Article Abstract:

Research presented concerns the genetic aspects of hepatocellular carcinoma or liver cancer. Topics addressed include oncogenic transformation, cell growth, and the relationship between gankyrin overexpression, the retinoblastoma gene, and hepatocarcinogenesis.

Japan, Statistical Data Included, Liver cancer, Hepatitis viruses, Oncogenes

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Selection, the mutation rate and cancer: ensuring that the tail does not wag the dog

Article Abstract:

The authors discuss the current focus on genomic mutation as a primary factor in cancer growth, since the mutation, of itself, does not cause tumor growth. They suggest expansion of that view to include the additional factors which lead to the growth of tumors.

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Signaling mismatch repair in cancer

Article Abstract:

Research on DNA mismatch repair defects will shed light on tumor development. Mutations in two human mismatch repair genes have been found in colorectal cancer, endometrial cancer, and ovarian cancer.

Health aspects, DNA repair

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