Promotion of sleep by targeting the orexin system in rats, dogs and humans

Article Abstract:

The analysis has shown that orexin, [OX.sub.1]/[OX.sub.2], receptor antagonists that passes the blood-brain barrier has caused somnolence in rats, dogs and humans when given during the active phase of their circadian cycle. Orexins have played a central role in regulating sleep-wake cycles and hence a wide range of sleep disorders might result from maladaptive orexinergic tone or disturbed circadian orexin release.

Author: Brisbare-Roch, Catherine, Dingemanse, Jasper, Koberstein, Ralf, Hoever, Petra, Aissaoui, Hamed, Flores, Susan, Muellar, Celia, Nayler, Oliver, van Gerven, Joop, de Haas, Sanne L., Hess, Patrick, Changbin Qiu, Buchmann, Stephan, Scherz, Michael, Weller, Thomas, Fischli, Walter, Clozel, Martine, Jenck, Francois
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
China, Europe, Blood-brain barrier, Antagonists (Biochemistry)

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA

TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity

Article Abstract:

A two-phase paradigm of autoimmunity associated with systemic lupus erythamatosus, the archrtypal autoimmune disease is formulated. The results show that both the phases depend on elaboration of type I interferons (IFNs), and therapeutic interruption of induction or activity of these cytokines in predisposed individuals might have substantial mitigation effect in lupus and other autoimmune diseases.

Author: Beutler, Bruce, Hoebe, Kasper, Baccala, Roberto, Kono, Dwight H, Theofilopoulos, Argyrios N
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
Science & research, Biological Product (except Diagnostic) Manufacturing, Biological products exc. diagnostic, Interferon, Autoimmune diseases, Systemic lupus erythematosus

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA

Changing the dosing schedule minimizes the disruptive effects of interferon on clock function

Article Abstract:

The impact drugs may have on the biological circadian rhythms and the importance of establishing proper dosage schedules to prevent adverse drug effects are examined, focusing on an experiment that demonstrates the disruptive effect of interferon on such biological processes as body temperature and clock-gene mRNA expression.

Author: Ohdo, Shigehiro, Koyanagi, Satoru, Suyama, Hinako, Higuchi, Shun, Aramaki, Hironori
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Japan, Statistical Data Included, Drugs, Complications and side effects, Adverse drug reactions

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Health aspects, Circadian rhythms, Research, Interferon
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.