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Placental sulfatase deficiency and congenital ichthyosis with intrauterine fetal death: case report

Article Abstract:

Congenital ichthyosis may cause placental sulfatase deficiency, or reduced levels of the enzyme sulfatase in the placenta of a developing fetus. Congenital ichthyosis is a genetic disorder that is characterized by dryness and fish-like scaling of the skin. Placental sulfatase deficiency was diagnosed in a 23-year-old patient during the 30th week of her fourth pregnancy. One of her earlier pregnancies had ended in a miscarriage, and another had been ectopic. Her son had been diagnosed with ichthyosis at the age of nine months. An ultrasound at 18 weeks of pregnancy had revealed a male fetus with normal development. The fetus died during the 39th week of pregnancy from possible hypoxia, or lack of oxygen. The death of the fetus may have been caused by placental sulfatase deficiency. The mother was probably a carrier of congenital ichthyosis, a condition carried on the female sex chromosome.

Abnormalities, Physiological aspects, X chromosome, Ichthyosis

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Reduced endothelial nitric oxide synthase activity and concentration in fetal umbilical veins from maternal cigarette smokers

Article Abstract:

The association between maternal cigarette smoking and endothelial nitric oxide synthase (eNOS) in fetal umbilical veins is examined. The findings suggest that maternal smoking leads to endothelial dysfunction due to the reduction of dilatory capacity of vessels and subsequently results in retarded fetal growth.

Research and Development in the Physical, Engineering, and Life Sciences, Science & research, Research and Testing Services, Gynecological R&D, Research, Causes of, Fetus, Fetal growth retardation, Gynecological research, Smoking in pregnancy

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