Osmotic lysis of tumor spill in ovarian cancer: a murine model

Article Abstract:

Irrigating the pelvic cavity with water does not appear to kill loose, floating cancer cells. Some doctors recommend this procedure in cases where cancerous ovarian cysts rupture in the hopes that any cancerous cells released will rupture and die from absorbing the water. However, researchers injected tumor cells into the pelvic cavities of mice and irrigated the pelvic cavity of some mice with pure water and others with salt water for comparison. Salt water should have no effect. The mice were followed for 60 days, by which time 97% of the mice showed tumor growth.

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The epigenetics of ovarian cancer drug resistance and resensitization

Article Abstract:

A prominent role for epigenetics, particularly aberrant DNA methylation and histone acetylation, in both intrinsic and acquired drug-resistance genetic pathways in ovarian cancer, is evaluated in a study. In particular, one such strategy for resensitization, based on the re-expression of drug sensitivity genes by reversal of epigenetic silencing, is analyzed.

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Ovarian cancer gene therapy: repeated treatment with thymidine kinase in an adenovirus vector and ganciclovir improves survival in a novel immunocompetent murine model

Article Abstract:

Injections of herpes simplex thymidine kinase and ganciclovir may be beneficial for women with ovarian cancer, according to a study in mice. Once injected, thymidine kinase activates ganciclovir, which can destroy cancer cells. The enzyme is delivered in an adenovirus.

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