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Juvenile psoriatic arthritis and HLA antigens

Article Abstract:

Juvenile psoriatic arthritis is an inflammatory joint disease that develops before the age of 16 years and is associated with psoriasis, a chronic skin disease. Psoriasis may develop before the onset of arthritis or may develop within the next 15 years following the onset of joint disease. Psoriasis often occurs between the ages of 5 and 15 years, and one-third of cases develop by age 15 years. Fewer than 150 cases of juvenile psoriatic arthritis have been reported. The clinical, laboratory, and X-ray findings were assessed in 28 patients with juvenile psoriatic arthritis. The genetic mechanisms underlying this disease were also examined. Results were compared with observations made in adults with psoriatic arthritis. The data show that psoriasis commonly precedes or occurs at the same time as the development of arthritis. Patients with juvenile psoriatic arthritis did not have uveitis, the inflammation of the uvea, which is the pigmented blood vessel layer of the eye. Ninety-three percent of patients had a good outcome, although eight of 28 patients required drug therapy for an average of nine years while they were being followed-up. The clinical features of juvenile psoriatic arthritis are similar to those of adult psoriatic arthritis with a similar duration of disease. Histocompatibility (HLA) antigens are elements present on all cells with a nucleus and are capable of provoking an immune response. Certain HLA have been detected in specific diseases. For example, there was an increased prevalence of B17 in both juvenile and adult psoriatic arthritis. In addition, juvenile psoriatic arthritis showed an increased prevalence of A2, while B27, Bw39, and Cw6 are prevalent in adult psoriatic arthritis. (Consumer Summary produced by Reliance Medical Information, Inc.)

Analysis, Physiological aspects, Demographic aspects, Histocompatibility antigens

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HLA antigens in psoriatic arthritis subtypes of a Spanish population

Article Abstract:

Psoriatic arthritis is the inflammation of the joint associated with psoriasis, a long-term skin disease. Studies have shown that susceptibility to psoriasis may increase with the presence of certain histocompatibility antigens (HLA), which are genetic elements present on all cells with a nucleus. HLA are capable of activating the immune system, are important in transplantation reactions, and may be predominant in certain diseases. The prevalence of various types of HLA was assessed in 104 Spanish patients with psoriatic arthritis. The patients were grouped according to their clinical features. HLA-B17, B27, B16, and Cw6 were most prevalent in patients with psoriatic arthritis, and HLA-B17/Cw6 occurred most often in patients with oligoarthritis (mild arthritis). HLA-B17 was most often detected in oligoarthritis and spondarthritis (the inflammation of the vertebrae), whereas Cw6 was more prevalent in oligoarthritis. B27/Cw1 occurred more often in spondarthritis, possibly due to a link between the B27 subtype called B27.5 and Cw1, whereas B44/Cw5 was decreased in psoriatic arthritis. Thus, the absence of certain HLA factors may account for the different clinical forms of psoriatic arthritis. (Consumer Summary produced by Reliance Medical Information, Inc.)

Measurement, Genetic aspects, Identification and classification, HLA histocompatibility antigens, Arthritis

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Dactylitis in psoriatic arthritis: a market for disease severity?

Article Abstract:

The acute dactylitis in patients with psoriatic arthritis, which often affects feet, and its relation to radiological changes are examined.

Canada, Diagnosis

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