Improved graft survival after renal transplantation in the United States, 1988 to 1996

Article Abstract:

The survival of kidney transplants has increased since 1988. Between 1988 and 1996, the half-life for kidney transplants increased from 12.7 years to 21.6 years. Ninety-four percent of kidney transplants from a living donor survived at least one year in 1996, compared to 89% in 1998. For kidneys from cadavers, the one-year survival rate increased from 76% to 88%. It is critical to make kidney transplants last as long as possible, because the number of people who need one exceeds the supply.

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The natural history of chronic allograft nephropathy

Article Abstract:

Almost all patients who receive a kidney transplant will develop disease in the transplanted kidney, according to a study of 120 patients with type 1 diabetes who received a kidney-pancreas transplant. Ten years after the operation, almost all the patients had disease in the transplanted kidney and 59% had severe kidney disease. This damage is irreversible, and may eventually cause the kidney to fail.

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Neointimal and tubulointerstitial infiltration by recipient mesenchymal cells in chronic renal-allograft rejection

Article Abstract:

Mesenchymal cells from an organ recipient can travel to the transplanted organ and begin the process of graft rejection. Researchers were able to determine this by looking for the male Y chromosome in kidney tissue taken from men and women who had received a kidney from a donor of the opposite sex.

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