Estrogen plus progestin and the risk of coronary heart disease
Article Abstract:
Hormone replacement therapy (HRT) should not be prescribed for healthy postmenopausal women to reduce their risk of developing coronary heart disease, according to the final results of the Women's Health Initiative study. This study of 16,608 postmenopausal women found that HRT actually increased their risk of developing coronary heart disease, particularly during the first year of use. The study was even stopped early because of this increased risk among HRT users.
author: Manson, Joann E., Trevisan, Maurizio, Johnson, Karen C., Heckbert, Susan R., Cushman, Mary, Stein, Evan, Rossouw, Jacques E., Hsia, Judith, Black, Henry R., Assaf, Annlouise R., Lasser, Norman L., Detrano, Robert, Strickland, Ora L., Wong, Nathan D., Crouse, John R.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
Complications and side effects, Hormone therapy, Hormone replacement therapy
Inflammatory markers and the risk of coronary heart disease in men and women
Article Abstract:
Plasma levels of soluble tumor necrosis factor receptors sTNF-R1 and sTNF-R2, interleukin-6, and C-reactive protein as markers of risk for coronary heart disease among women participating in the Nurses' Health Study and men participating in the Health Professionals Follow-up Study in nested case-control analyses are examined. Elevated levels of inflammatory markers, particularly C-reactive protein, indicate an increased risk of coronary heart disease.
author: Rifai, Nader, Stampfer, Meir J., Manson, Joann E., Rimm, Eric B., Hankinson, Susan E., Curhan, Gary C., Pischon, Tobias, Jing Ma, Pai, Jennifer K., Joshipura, Kaumudi, Cannuscio, Carolyn C.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
United Kingdom, Science & research, Care and treatment, Research, C-reactive protein, Tumor necrosis factor, Tumour necrosis factor
Estrogen therapy and coronary-artery calcification
Article Abstract:
A random clinical study aimed to ascertain the relation between estrogen therapy and calcification in the coronary artery, and the results are documented.
author: Robbins, John, Kuller, Lewis H., Carr, J. Jeffrey, Prentice, Ross L., Hsia, Judith, Gass, Margery, Cochrane, Barbara B., Manson, JoAnne E., Langer, Robert T., Allison, Matthew A., Rossouw Jacques E., Hunt, Julie R., Ludlam, Shari E., Pettinger, Mary B., Nathan, Lauren, Okene, Judith K., Margolis, Karen M., Stefanik, Marcia
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Estrogen & Progestogen Preps, Health aspects, Patient outcomes, Estrogen, Estrogens, Calcification, Clinical report
subjects list: Risk factors, Coronary heart disease
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