Edema of the bone marrow can cause pain in osteoarthritis and other diseases of bone and joints

Article Abstract:

It is possible that swelling in the bone marrow causes the pain that most patients with osteoarthritis feel. Many patients have pain even though their joint disease is not severe and many patients with severe disease don't have pain. But the bone marrow may be injured and this may be what causes the pain.

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Pain: moving from symptom control toward mechanism-specific pharmacologic management

Article Abstract:

The different types of pain nonreceptive, inflammatory, neuropathic, functional and the neurobiological mechanisms are discussed. A major advance in the understanding of pain is identification of the multiple mechanisms responsible for production of distinct pain syndromes and their molecular components.

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The association of bone marrow lesions with pain in knee osteoarthritis

Article Abstract:

Abnormalities in bone marrow may cause the pain that most patients with osteoarthritis feel. This could explain why pain occurs, since the cartilage in joints does not contain nerve cells.

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