A comparison of levomethadyl acetate, buprenophine, and methadone for opioid dependence

Article Abstract:

Levomethadyl acetate, buprenorphine, and high-dose methadone are more effective in treating opioid addiction than low-dose methadone. This was the conclusion of a study of 112 drug addicts.

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Dose-related efficacy of levomethadyl acetate for treatment of opioid dependence: a randomized clinical trial

Article Abstract:

Treatment with levomethadyl acetate can significantly reduce opioid use among drug addicts. This drug was approved for the treatment of opioid dependence in 1993. A total of 180 drug addicts took low-dose, medium-dose or high-dose levomethadyl acetate three times a week. Thirty-four percent of the group taking the high-dose abstained from opioid use for four weeks compared to 14% of those taking the medium dose and 11% of those taking the low dose. High doses of the drug reduced opioid use by 90% compared to pre-treatment use.

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Moderate- vs High-Dose Methadone in the Treatment of Opioid Dependence: A Randomized Trial

Article Abstract:

Higher doses of methadone may be more effective in treating addiction to opiates. Researchers randomly assigned 192 opiate addicts to take a moderate dose of 40 to 50 milligrams of methadone every day or a high dose of 80 to 100 milligrams. Patients in the high-dose group were less likely to have opiates in their urine samples. Thirty-three percent of the patients in the high-dose group completed the treatment compared to 20% of the patients in the moderate-dose group.

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