The effects of pregnancy and smooth muscle contractility on cervical distensibility in the rat

Article Abstract:

The softening of the cervix as pregnancy progresses is not dependent on smooth muscle activity. This was the conclusion of researchers who found that rat cervixes softened as pregnancy progressed whether the cervical smooth muscles were contracted or relaxed.

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Degranulation of uterine mast cell modifies contractility of isolated myometrium from pregnant women

Article Abstract:

A study is conducted to test that the uterine mast cell degranulation alters human myometrial contractility in vitro and to define what mediators are involved in this process. Results indicate that uterine mast cell degranulation, or the effects of their mediators, can modulate uterine contractility during pregnancy.

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Both soluble guanylate cyclase and particulate guanylate cyclase regulate myometrial contractility

Article Abstract:

Uterine contractions are regulated by guanylate cyclase in its soluble and particulate forms. Guanylate cyclase is an enzyme that creates cyclic GMP. The enzyme can occur in body fluids in a soluble form or in a membrane as the particulate form. Researchers put samples of rat uterus in culture and stimulated them with nitric oxide and atrial natriuretic peptide, which stimulate the soluble and particulate form of the enzyme, respectively. Both chemicals inhibited uterine contraction.

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