Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease

Article Abstract:

Deep brain stimulation using implanted electrodes can inhibit the involuntary movement disorders in patients with Parkinson's disease, according to a study of 134 patients. The electrodes can inhibit specific areas of the brain without destroying brain tissue.

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Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia

Article Abstract:

A prospective, controlled, multicenter study is conducted to assess the efficacy and safety of bilateral pallidal stimulation in 22 patients with primary generalized dystonia. The results reveal that the general health and physical functioning improved and there are no significant changes in measures of mood and cognition.

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Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease

Article Abstract:

Electrical stimulation of a brain area called the subthalamic nucleus appears to be beneficial in patients with advanced Parkinson's disease. Many Parkinson's patients experience "off" periods when they do not respond to levodopa, the major drug used to treat the disease. Researchers implanted electrodes into the subthalamic nucleus in 24 Parkinson's patients. The electrodes were attached to an electrical generator that was placed under the skin like a heart pacemaker. After one year of stimulation, the dose of levodopa could be reduced and symptoms were less severe.

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