DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy

Article Abstract:

Immunohistochemical analysis is used to determine the expression of the excision repair cross-complementation group 1 (ERCC1) protein in operative specimens of non-small-cell lung cancer through comparison of the effect of adjuvant cisplatin-based chemotherapy on survival. Patients with completely resected non-small-cell lung cancer and ERCC1-negative tumors appear to benefit from adjuvant cisplatin-based chemotherapy, whereas patients with ERCC1-positive tumors do not.

Author: Tursz, Thomas, Sabatier, Laure, Pignon, Jean-Pierre, Soria, Jean-Charles, Olaussen, Ken A., Dunant, Ariane, Fouret, Pierre, Brambilla, Elisabeth, Andre, Febrica, Haddad, Vincent, Taranchon, Estelle, Filipits, Martin, Pirker, Robert, Popper, Helmut H., RolfStahel, M.D., Le Chevalier, Thierry
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
Genetic aspects, Chemotherapy, Lung cancer, Non-small cell, Non-small cell lung cancer, Cisplatin

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Tyrosine Kinases as targets for cancer therapy

Article Abstract:

Protein Tyrosine Kinases (TKs) are enzymes that catalyze the transfer of phosphate from ATP to tyrosine residues in polypeptides. The mechanisms of aberrant TK signaling and strategies to inhibit TKs in cancer are reviewed, the status of TK-directed cancer therapies is summarized, and the challenges and prospects for the future are discussed.

Author: Krause, Daniela S., Etten, Richard A. Van
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
Methods, Protein kinases, New England

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Curing Cancer with p53

Article Abstract:

The activity of p53 tumor suppressor protein plays an important role in controlling cancer. Such a progress will further encourage the investment needed to support clinical trials.

Author: Lane, David
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
Clinical trials

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Subjects list: Health aspects, Research, Cancer, Cancer treatment
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