Caspase inhibition reduces apoptosis and increases survival of nigral transplants

Article Abstract:

The authors state that general rejection of fetal brain tissue transplanted to alleviate Parkinson's disease can be reduced. Generally, only 5-10% of the tissue survives, but prevention of apoptosis can improve that percentage and reduce the amount of the severely limited transplant tissue which is needed.

Author: Brundin, Patrik, Widner, Hakan, Nicotera, Pierluigi, Schierle, Gabriele S., Hansson, Oskar, Leist, Marcel
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
Health aspects, Research, Physiological aspects, Cell death, Parkinson's disease, Parkinson disease, Fetal tissue transplantation

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Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

Article Abstract:

Gene therapy for glioblastoma that uses an adenoviral vector may cause inflammation in the brain. This was discovered in patients who received the herpes simplex virus 1 thymidine kinase gene, which suppressed glioma growth but caused inflammation and demyelination.

Author: Stone, D., Dewey, R.A., Morrissey, G., Cowsill, C.M., Bolognani, F., Dodd, N.J.F., Southgate, T.D., Klatzmann, D., Lassmann, H., Castro, M.G., Lowenstein, P.R.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
Care and treatment, Complications and side effects, Gene therapy, Brain, Inflammation, Glioblastoma multiforme

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