Atrial natriuretic peptide levels in the prediction of congestive heart failure risk in frail elderly
Article Abstract:
Elderly patients who have a history of congestive heart failure (CHF) and elevated blood levels of atrial natriuretic peptide (ANP) have a high risk of developing CHF. ANP is a hormone produced by the heart in response to increased blood volume. A total of 310 elderly patients in a nursing home had a history and physical, and their blood ANP was measured. The patients were followed for one year. When they were grouped according to their blood ANP levels, 36% of the group with the highest levels had an episode of CHF during the year, compared to two percent of the group with the lowest levels. An ANP level of 200 picomoles per liter was found to be the value that would best predict who would have an episode of CHF. Using previous history of CHF and ANP levels, the patients could be divided into three groups: those who had a low risk of CHF, those who had a moderate risk and those who had a high risk.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1992
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Major Cardiovascular Events in Hypertensive Patients Randomized to Doxazosin vs Chlorthalidone: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
Article Abstract:
Doxazosin appears to increase the risk of congestive heart failure compared to other antihypertensive drugs. This was the conclusion of researchers who randomly assigned 24,335 patients with hypertension to take either doxazosin or chlorthalidone, which is a diuretic. Doxazosin belongs to a class of drugs called alpha-blockers. Over and average follow-up of three years, the risk of heart attack was similar in both groups. However, patients who took doxazosin had twice the risk of congestive heart failure and a higher risk of stroke compared to patients taking the diuretic.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2000
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Insulin resistance and risk of congestive heart failure
Article Abstract:
Studies were conducted to explore whether insulin resistance predicts congestive heart failure (CHF) and provide the link between obesity and CHF. The findings indicate that insulin resistance predicted CHF incidence independently of established risk factors including diabetes in large community-based sample of elderly men.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2005
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