An evaluation of the carcinoembryonic antigen (CEA) test for monitoring patients with resected colon cancer
Article Abstract:
The carcinoembryonic antigen (CEA) test may not be an effective method for diagnosis of a recurrence of colon cancer. CEA is a protein secreted by colon cancer cells into the lining of the gastrointestinal tract. Among 1,017 colon cancer patients who were monitored with CEA testing, 417 had a cancer recurrence and 600 did not. An increase in CEA concentration occurred before diagnosis in 59% of the patients who had a cancer recurrence. CEA testing was most sensitive for the detection of metastatic cancer in the liver or in the retroperitoneal space. It was least sensitive for the detection of a cancer recurrence in the colon, lungs or peritoneum, or the lining of the abdominopelvic walls. Sixteen percent of the patients who did not have a cancer recurrence had false-positive CEA test results.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer
Article Abstract:
Chemotherapy with cisplatin can prolong the lives of patients with non-small-cell lung cancer who have their tumor surgically removed, according to a study of 1,867 patients. Five years after this treatment, 44% of those who received cisplatin were alive compared to 40% who did not. Those who received cisplatin also lived longer before their cancer returned.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Molecular predictors of survival after adjuvant chemotherapy for colon cancer
Article Abstract:
The loss of chromosome 18q appears to worsen the prognosis of colon cancer whereas a mutation in the gene for transforming growth factor beta1 improves the patient's prognosis. This was the conclusion of a study of 460 patients with colon cancer who had chemotherapy.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Prognostic value of immunohistochemically identifiable tumor cells in lymph nodes of patients with completely resected esophageal cancer
- Abstracts: Placental production of estradiol and progesterone after oocyte donation in patients with primary ovarian failure
- Abstracts: Suicide risk and treatments for patients with bipolar disorder. A 25-Year-Old Woman With Bipolar Disorder
- Abstracts: Pharmacotherapy for heart failure in patients with renal insufficiency. Ibopamine: a drug that has opposite effects depending on the severity of a patient's disease
- Abstracts: Hormone replacement therapy for bone protection in multiparous women: when to initiate it. Selection of oral contraceptives or hormone replacement therapy: patient communication and counseling issues