1The HPTN 024 study: The efficacy of antibiotics to prevent chorioamnionitis and preterm birth

Article Abstract:

A study was conducted to determine if antibiotics given prenatally and during labor reduce the incidence of preterm birth and histologic chorioamnionitis. It was concluded that despite reducing the rate of vaginal infections, the antibiotic regimen used in the study did not reduce the rate of preterm birth, increase the time to delivery, or increase birth weight.

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Preconceptional antibiotic treatment to prevent preterm birth in women with a previous preterm delivery

Article Abstract:

A study was conducted to address the question of whether the uterine cavity is normally sterile. The difficulties in conducting microbiologic studies of the endometrium, the limitations of conventional microbiologic techniques and the potential contribution of molecular microbiology were reviewed to examine microbial diversity and burden of endometrium.

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The transcriptome of the uterine cervix before and after spontaneous term parturition

Article Abstract:

The differentially expressed genes in human uterine cervix transcriptome in women not in labor term and women who underwent spontaneous term labor are identified. The analysis has provided an unbiased and comprehensive description of the changes in the cervical transcriptome before and after spontaneous term labor.

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