Iron and heart disease: the epidemiologic data

Article Abstract:

Current evidence does not appear to suggest that higher levels of iron in the body are associated with a higher risk of coronary heart disease. The Oxidative Stress Theory suggests that increased iron levels would catalyze the formation of increased amounts of free radicals that could damage tissue and cause diseases such as coronary heart disease. Despite a Finnish study linking iron levels to heart attacks, most epidemiological evidence runs contrary to this hypothesis.

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Effects of positive iron status at a cellular level

Article Abstract:

Many diseases may involve the mobilization of iron stores in the body that can cause damage via lipid peroxidation. Excess iron cannot be eliminated by the body. Instead, iron is stored in a complex with the ferritin protein. Disease processes involving the production of superoxide free radicals cause the release of iron from this complex. The released iron can cause formation of potent hydroxyl radicals, which can promote lipid peroxidation.

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Coxsackievirus as a model of viral evolution driven by dietary oxidative stress

Article Abstract:

Research presented concerns the relationship between human nutrition and viral virulence, focusing on the impact of selenium deficiency on Keshan disease and coxsackievirus infections. Topics addressed include how the biological and genetic characteristics of the coxsackievirus can be altered by oxidative stress in the host.

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