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Glucocorticoids inhibit intestinal phosphate absorption in developing rabbits

Article Abstract:

Osteoporosis associated with glucocorticoid therapy was investigated by giving pharmacologic doses of methylprednisolone intravenously to suckling rabbits The results showed a decrease in phosphate transport across the brush border of the small intestines. This is due to the direct inhibitory effect of the steroid on sodium-phosphate cotransport across the membrane barrier although passive diffusion remains constant. This implies no permeability defect on the small intestine nor is the stoichiometry of molecular transport affected by its administration.

Analysis, Causes of, Complications and side effects, Adrenocortical hormones, Phosphates, Osteoporosis, Intestinal absorption

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A mixture of nucleosides and a nucleotide alters hepatic energy metabolism 24 hours after hepatectomy in rabbits

Article Abstract:

A nucleoside-nucleotide mixture has been used with success as a dietary supplement in hepatic pathological studies. The effect of administering this mixture on hepatic energy metabolism 24 hours after hepatectomy was investigated. Results showed that the mixture suppressed the enhancement of hepatic mitochondrial adenosine triphosphate (ATP) generation. This enhancement is important because cellular regeneration consumes ATP. Use of the mixture may be appropriate only after the hepatic energy deficit resulting from surgery has been overcome.

Care and treatment, Liver, Energy metabolism, Metabolic regulation, Hepatectomy, Liver regeneration

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Modification of the clastogenic activity of x-ray and 6-mercaptopurine in mice by prefeeding with vitamins C and E

Article Abstract:

The mouse bone marrow micronucleus test was used to study the effect of vitamins C and E on the chromosome-damaging activity of x-rays and 6-mercaptopurine. It was shown that water treatment with vitamin C reduces micronucleus formation induced by x-rays as compared with treatment of vitamin E. It was therefore concluded that maximal protection from the hazardous effects of x-rays can be obtained with high levels of vitamin C in water and vitamin E supplemented diets.

Health aspects, Vitamin E, X-rays, Vitamin C, Mercaptopurine

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