Article Abstract:
A study was conducted to analyze the influence of alcohols on well-defined lipid bilayers. Isothermal titration calorimetry was utilized to determine the excess partial molar enthalpy of alcohol in liposome suspensions. Calorimetric data were then used to examine molecular interactions. Results indicated a maximum in partitioning coefficients in the transition region resulting from the formation of heterogenous lateral bilayers characterized by fluctuating lipid domains and interfacial regions acting as adsorption sites.
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Article Abstract:
Volume changes associated with the partitioning of light different alcohols and acetone into unilamellar vesicles of dimyristoyl phosphatidylcholine in the fluid state was investigated by newly designed, automated, titration densitometric equipment. The modes of interactions that underline the partitioning of small molecules into membranes are of central importance for the elucidation of a number of biological and pharmacological mechanisms.
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Article Abstract:
Research was conducted to examine the intermolecular interactions in tert-butyl alcohol-dimethyl sulfoxide-H2O. The excess chemical potentials, the partial molar volumes and the excess partial molar entropies in tert-butyl alcohol (TBA)-dimethyl sulfoxide (DMSO)-H2O mixtures were identified. Collected data were utilized in the evaluation of intermolecular interactions. Results indicate that the effect of TBA and DMSO on H2O is additive.
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