Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains

Article Abstract:

A class of binding proteins, called avimers is developed to overcome the limitations of antibodies and other immunoglobulin-based therapeutic proteins. Linking multiple independent binding domains creates avidity and results in improved affinity and specificity compared with conventional single-epitope binding proteins.

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Ordered surface carbons distinguish antifreeze proteins and their ice-binding regions

Article Abstract:

A generic ice-binding model is formulated and incorporated it into a physicochemical pattern-recognition algorithm. Results show that the algorithm is used to identify a novel antifreeze protein (AFP) from winter rye, and the antifreeze activity of this protein was subsequently confirmed.

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Isjolation of high-affinity ligand-binding proteins by periplasmic expression with cytometric screening (PECS)

Article Abstract:

Ligand-binding proteins can be isolated from diverse libraries utilizing periplasmic expression with cytometric screening (PECS)

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