Article Abstract:
A P-lacZ gene locus at 49B, labeled as frazzled, was identified as a Drosophila member of the gen family of deleted in colorectal cancer (DCC). The frazzled mutated gene induces alterations in the development and function of the Drosophila nervous system after it is expressed in the axons and epithelia during embryogenesis. However, the DCC-related frazzled gene is not expressed in target tissues indicating its functional role as a mediator of cellular guidance via neuronal gene expression.
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Article Abstract:
Scientific evidences have revealed the important role of alpha satellite, also known as alphoid DNA, in centromere function. This is the only known DNA localized in the centromeric regions of all normal human chromosomes. Moreover, natural and artificial chromosome rearrangements have been used to localize human X and Y centromeres. However, these evidences failed to consider the role of nonalphoid DNAs.
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Article Abstract:
The nod+, a kinesin-like gene needed for the meiotic transmission of achiasmate chromosome, helps in the transmission of the Drosophila minichromosome Dp1187. The chromosome transmission develops forces outside the kinetochore for the attachment of achiasmate chromosome to the metaphase spindle. The nod interactions are seen at a region which is not required for centromere function.
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