TGF-beta regulation by Emilin1: New links in the etiology of hypertension
Article Abstract:
Hypertension is a complex disease influenced by multiple genetic and environmental factors and the TGF-beta signaling pathway has a long recognized role in blood pressure homeostasis. The secreted protein Emilin1 is a negative regulator of TGF-beta signaling and Emilin1 knockout mice display elevated blood pressure due to increased TGF-beta signaling in the vasculature.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Bmp signaling: Turning a half into a whole
Article Abstract:
The basis of the phenomenon that amphibians have a remarkable ability to compensate for perturbations to the embryo is presented. It is demonstrated that interactions between bone morphogenetic proteins (Bmps) and their inhibitors on both the dorsal and ventral sides of the early Xenopus embryo are involved in creating the body plan.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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