Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization

Article Abstract:

The molecular basis of vascular stabilization regulated by sphingosine 1-phosphate (S1P), a platelet-derived lipid mediator is investigated. S1P-induced trafficking and activation of N-cadherin provides a novel mechanism for the stabilization of nascent blood vessels by mural cells and may be exploited to control angiogenesis and vascular diseases.

Author: Han, David K., Proia, Richard L., Paik, Ji-Hye, Skoura, Athanasia, Sung-suk Chae, Cowan, Ann E.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
Sphingosine

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The PTEN/P13K pathway governs normal vascular development and tumor angiogenesis

Article Abstract:

Study is conducted in which Cre-loxP system was used to generate an endothelial cell-specific mutation of Pten(Tie2CrePten) in mice. Tie2CrePten(sub flox/+) mice showed enhanced tumorigenesis due to increase in angiogenesis driven by vascular growth factors, which was partially dependent on P13K subunits p85alpha and p110gamma.

Author: Suda, Toshio, Sasaki, Takehiko, Horie, Yasuo, Nakao, Kazuwa, Itoh, Hiroshi, Hamada, Koichi, Koni, Pandelakis A., Natsui, Miyuki, Kishimoto, Hiroyuki, Sasaki, Junko, Yajima, Nobuyuki, Hasegawa, Go, Naito, Makoto, Miyazaki, Jun-ichi, Mak, Tak Wah, Nakano, Toru; Suzuki, Akhira
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
Japan, Health aspects, Analysis, Tumor suppressor genes, Rats, Structure, Rattus, Apoptosis, Tumour suppressor genes

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A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging

Article Abstract:

Coregulator DIN-1 and DAF-12 is shown interacting physically and genetically to instruct organismal fates. It is proposed that the DIN-1S/DAF-12 complex serves as a molecular switch that implements slow life history alternatives in response to diminished hormonal signals.

Author: Antebi, Adam, Ludewig, Andreas H., Weitzel, Cindy, Neubert, Kerstin, Bethke, Axel, Gerisch, Brigit, Hutter, Harald, Kober-Eisermann, Corinna
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
Canada, Lipid metabolism

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Subjects list: Research, Neovascularization, Receptor antibodies, Genetic aspects
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