Biofilm resistance to antimicrobial agents

Article Abstract:

Antibiotics may damage but not kill the organisms on the surface of biofilms. These organisms would then shield the organisms below them from nutrients that would arouse them from their dormant state, making them susceptible to the drug. This could explain why biofilms are more resistant to antibiotics.

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Spatial patterns of alkaline phosphatase expression within bacterial colonies and biofilms in response to phosphate starvation

Article Abstract:

Research was conducted to examine spatial patterns of starvation gene expression within bacterial biofilms and colonies. Enzyme expression patterns were studied in both Pseudomonas aeruginosa and Klebsiella pneumoniae biofilms. Results are in good agreement with the hypothesis that alkaline phosphatase expression patterns are primarily controlled by the local availability of the electron acceptor or the carbon and energy source.

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Spatial physiological heterogeneity in Pseudomonas aeruginosa biofilm is determined by oxygen availability

Article Abstract:

A study was conducted to analyze the function of oxygen availability on the physiological activity of Pseudomonas aeruginosa in biofilms. A drip-flow reactor was utilized to cultivate the biofilms. Experimental results indicated marked spatial physiological heterogeneity within P. aeruginosa biofilms wherein protein synthesis is hindered by the availability of oxygen to the upper 30 microns of the biofilm.

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