Article Abstract:
B-cell epitope analyses of the serotype 15 PorB protein in Neisseria meningitidis were conducted by screening paired sera from selected patients with systemic meningococcal disease (SMD) with synthetic 12mer peptides spanning the PorB protein sequence, and/or its variable region 1 (VR1). D63b2, a 23mer soluble peptide that covered the VR1 region, was found to substantially inhibit IgC binding to the denatured PorB protein on immunoblots, indicating that this B-cell epitope was one of the main linear epitopes on the PorB protein recognized by sera from some SMD patients.
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Article Abstract:
The Norwegian serogroup B meningococcal outer-membrane vesicle (OMV) vaccine initiates the release of antibiotics specific for human linear BCE present in the serotype 15 protein loop. Synthetic peptides of class 3 OMP were prepared on pins and screened with serum of Norwegian adolescents immunized with meningococcal serogroup B OMV vaccine. There was an increase in the number of IgG antibodies apart from heterogeneity in IgG concentration.
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Article Abstract:
Differences in opacity gene pools are examined through a comparative analysis of opa genes from the FAM18 strain of ET-37 complex isolate from the USA and opa genes from four related ET-37 complex Neisseria meningitidis strains from Mali, West Africa. Experiments show that different Opa repertories were formed through recombinational reassortment. Both genes feature shared and unique opa HV regions.
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