Identification of mouse sperm SED1, a Bimotif EGF repeat and discoidin-domain protein involved in sperm-egg binding

Article Abstract:

Research identifies SED1 protein which is homologous to cell-matrix adhesive proteins and contain Notch-like epidermal growth factor repeats and discoidin/F5/8 type C domains. SED1 is localized to the sperm plasma membrane and mediates sperm binding to the egg zona pellucida. SED1 specifically binds to the unfertilized oocytes and not to the fertilized eggs.

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The European Research Council on the brink

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The European Research Council was created to fund basic scientific research throughout the European Union and might be in non-EU countries also. This agency faces the challenge of building a structure that is independent and transparent and should have a significant influence on science.

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Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission

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Results demonstrate identification of an orphan protein representing the classical amino acid transport system N (SN1). The data indicate that SN1 mediates glutamine efflux and uptake associated with the nitrogen metabolism and is involved in the sodium ion and proton transoport.

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