Article Abstract:
Specialized cells acting as pacemakers generate the rhythmic, spontaneous firing of action potentials, which can control muscle activity and certain autonomic functions. These cells are important on the electrical activity of the heart and brain. Cardiac arrhythmias and various neurological diseases can be attributed to the abnormalities in the pacemaker activity which is generated by a hyperpolarization-activated channel that is permeable to sodium and potassium and is regulated by cyclic nucleotides.
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Article Abstract:
The influence of HCN1 channels on CA1 pyramidal cell physiology, synaptic integration and induction of LTP at inputs to CA1 pyramidal cells, as well as hippocampal network activity, and hippocampal-dependent forms of learning and memory is examined. It is suggested that HCN1 channels constrain learning and memory by regulating dentritic integration of distal synaptic inputs to pyramidal cells.
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Article Abstract:
Research demonstrates that HCN1 channel is essential both for learning and memory of motor behaviors of relatively rapid, repeated, and coordinated movements and in integration of inputs by cerebellar Purkinje cells. Data show that HCN1 stabilizes Purkinje cell generated input-outut properties thus facilitating plasticity in the cerebellar cortex, which modulate the repetitive motor activity.
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