Identification of Flt(super 3+) lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment

Article Abstract:

A study conducted presents an evidence for a population of cells, which although sustaining a high proliferative and combined lympho-myeloid differentiation potential, have lost the ability to adopt erythroid and megakaryocyte lineage fates. It is shown that cells in the Lin(super -1)Sca-1(super +1)-kit(super +1) hematopoietic stem cell (HSC) compartment coexpressing high levels of the tyrosine kinase receptor Flt3 sustains granulocyte, monocyte, and B and T cell potentials.

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Cytokines regulate postnatal hematopoietic stem cell expansion: Opposing roles of thrombopoietin and LNK

Article Abstract:

Studies were conducted to identify thrombopoietin (THPO) and find out whether LNK can act as a physiological regulator of cytokine-induced hematopoietic stem cell (HSC) expansion. This expansion is highly selective for self-renewing long-term HSCs, showing enhanced THPO responsiveness, within stem cell compartment.

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BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties

Article Abstract:

The presence and the importance of the bone morphogenetic proteins (BMPs) in dermal papilla (DP) cells are discussed. The BMP signaling is found to be extremely significant for the key signature features and hair follicle-inductive properties of these cells.

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