Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

Article Abstract:

A flexible mouse model of liver cancer is used to search for spontaneous mutations arising in tumors initiated by different oncogenic lesions and it is then compared to alterations observed in human cancers. The model has not only identified two oncogenes in the same focal amplification that cooperate during tumerogenesis but has also highlighted the use of integrating mouse models and cancer genomics for the functional annotation of cancer genes.

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Principles of tumor suppression

Article Abstract:

The importance of earlier studies on molecular genetic of familial cancer syndromes which identified and defined the recessive nature of tumor suppressor genes in contemporary cancer research is presented. The regulation of diverse cellular activities, like mitogenic signaling, repair of DNA damage and protein ubiquitination and degradation by tumor suppressor genes is highlighted.

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Slugging it out: Fine tuning the p53-PUMA death connection

Article Abstract:

The transcription factor SLUG is induced by p53 protects hamatopoietic progenitor cells from apoptosis triggered by DNA damage. The SLUG exerts the protective role by repressing puma, a proapoptotic target of p53 and is also key coordinator of apoptosis mediated by both nuclear and cytoplasmic functions of p53.

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