Defective processing of methylated single-stranded DNA by E. coli alkB mutants

Article Abstract:

Processing of methylated single-stranded DNA by Escherichia coli alkB mutants and its defects are discussed. Data show alkB mutants have a marked defect in processing methylation damage in single-stranded DNA. AlkB may act on alkylated single-stranded DNA at transcribed regions or in replication forks. Stationary phase alkB cells were less methylmethanesulfonate (MMS)-sensitive than fast-growing cells, which supports that hypothesis.

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The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor

Article Abstract:

Kaiso, a p120 catenin partner, has been found to be a DNA methylation-dependent transcriptional repressor. A novel mammalian DNA binding activity that must have at least two symmetrically methylate CpG dinucleotides in its recognition sequence, preferably in the sequence 5'CGCG is described. Zinc-finger motifs appear to be responsible for DNA binding.

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Identification and purification of two distinct complexes containing the five RAD51 paralogs

Article Abstract:

Identification and purification has been carried out for two distinct complexes containing the five RAD51 paralogs. The extreme sensitivity of paralog-defective cell lines to cross-linking agents has been found to be traceable to defects in the processing of incised cross links and to resulting failure to start recombinational repair at certain sites.

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