Hypoxia-inducible factor-1 and oncogenic signalling

Article Abstract:

The underlying mechanism involved in the activation of Hypoxia-inducible factor-1 (HIF-1) in response to both hypoxic stress and oncogenic signals has an impact on how these processes may become deregulated in human cancer. A better understanding of this regulation may provide a basis for the development of new cancer therapies.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Physiological relevance of telomeric G-quadruplex formation: A potential drug target

Article Abstract:

The physiological relevance of G-quadruplex stabilizing agents and their potential pitfalls are discussed. The inability of telomerase to utilize a G-quadruplex folded telomeric substrate has led to the emergence of G-quadruplex stabilizing agents, which can be used as an effective strategy for controlling cancer.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Anti-cancer selection as a source of developmental and evolutionary constraints

Article Abstract:

Cancer has a negative effect on fitness and has been looked from an evolutionary perspective. Various alternative developmental links cancer may have together with their evolutionary implications is discussed with the help of inputs from Kavanagh and Leroi et al.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: