Article Abstract:
Directed actin polymerization, the underlying force for epithelial cell-cell adhesion, is discussed relative to an investigation of adherens junctions (AJ) formation in primary mouse keratinocytes, leading to novel insights. Ephithelial cells have been found to engage in a process of cadherin-mediated intercellular adhesion that uses calcium and actin polymerization in unanticipated ways. AJs are intercellular structures prominent in epithelia and neurons. Present understanding of AJ formation lacks satisfactory mechanisms to explain formation of puncta and actin dynamics.
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Article Abstract:
Research has been conducted on the surface epithelium conditionally targeted for the alpha-catenin ablation. Results indicate that due to this epithelium targeting the hair follicle development has been blocked and the epidermal morphogenesis has been affected.
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Article Abstract:
A novel BPAG1 neural isoform that possesses a microtubule-binding domain was determined which can preferentially associate with microtubules. Such isoform has the ability to interconnect the three cytoskeletal networks, namely actin filaments, microtubules and intermediate filaments. Analysis also reveals that microtubules in cultured neurites that lack BPAG1 tend to exhibit hypersensitiveness. Such phenomenon can be attributed to BPAG1's domain which enables foreign microtubule networks to be stable.
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