Human pedigree-based quantitative-trait-locus mapping: localization of two genes influencing HDL-cholesterol metabolism
Article Abstract:
Genes located on chromosome 8 and chromosome 15 appear to influence HLD-cholesterol metabolism., according to results of a full genomic scan. Multivariate analyses indicate that the locus on chromosome 8 affects unesterified cholesterol levels, while the locus on chromosome 15 affects concentration of HDL-cholesterol as well as how cholesterol is distributed among different particle sizes of HDL. Data were derived from Mexican American families in the San Antonio Family Heart Study.
author: Stern, Michael P., Blangero, John, Williams, Jeff T., VandeBerg, John L., MacCluer, Jean W., Rainwater, David L., Mahaney, Michael C., Almasy, Laura, Hixson, James E., Cole, Shelley
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
Physiological aspects, Cholesterol, HDL, HDL cholesterol lipoproteins, Cholesterol metabolism
Genotype x adiposity interaction linkage analyses reveal a locus on chromosome 1 for lipoprotein-associated phospholipase [A.sub.2], a marker of inflammation and oxidative stress
Article Abstract:
The samples from the San Antonlo Family Heart Study are used to test the hypothesis that the contribution of genes to variation in a biomarker of low-grade inflammation and oxidative stress are influenced by the degree of adiposity. Results reveal the possibility of a significant response to the adiposity environment in lipo-protein-associated phospholipase (Lp-[PLA.sub.2]), which is an important biomarker of inflammation and oxidative stress.
author: Dyer, Thomas D., Blangero, John, Williams, Jeff T., Cole, Shelley A., MacCluer, Jean W., Comuzzie, Anthony G., Diego, Vincent P., Rainwater, David L., Xing-Li Wang, Curran, Joanne E., Johnson, Matthew P., Jowett, Jeremy B.M., Moses, Eric K., Mahaney, Michael C.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
Science & research, Chromosomes, Lipoproteins, Phospholipases, Structure, Proteolipids, Oxidative stress, Report
Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans
Article Abstract:
Studies support the location of type 2 diabetes susceptibility in Mexican Americans on chromosome 10q. Using a variance-components process to perform multipoint linkage analyses on 440 Mexican American subjects, researchers found a susceptibility locus near the D10S587 marker that not only influences type 2 diabetes but age at onset as well.
author: Stern, Michael P., Dyer, Thomas D., Blangero, John, Almasy, Laura, Leach, Robin J., Duggirala, Ravindranath, Williams, Kenneth L., O'Connell, Peter
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
United States, Health aspects, Diabetes, Diabetes mellitus, Mexican Americans, Chromosome abnormalities
subjects list: Genetic aspects, Research
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