Article Abstract:
A novel BCL-6 interacting corepressor, BCoR, has been identified, characterized, and found to be involved in BCL-6 repression and perhaps BCL-6-associated lymphomas. BCoR can act as a corepressor when tethered to DNA and can potentiate BCL-6 repression when overexpressed. Certain class I and II histone deacetylases (HDACs) interact in vivo with BCoR. This indicates that BCoR may interact selectively with the POZ domain of BCL-6, but not with eight additional POZ proteins tested, PLZF included.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
Dual use of an acceptor/donor splice site has been found to govern alternative splicing of the interferon regulatory factor-3 (IRF-3) gene. The alternative spice isoform, IRF-3a, encoded by the IRF-3 gene is expressed in all tissues and cell lines tested. Ratios of IRF-3a to IRF3 mRNA are varied. Sequences downstream from the unusual splice junction can bind members of the ST protein family. This can affect splice site selection.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
Studies show the binding of human papillomavirus 16 E6 (HPV16 E6) to interferon regulatory factor-3 (IRF-3) prevents the interferon's transcriptional activity. This binding process does not create degradation or ubiquitination of HPV16 E6, and by inhibiting IRF-3's transcriptional activity, HPV16 E6 may be able to circumvent antiviral cellular response.
User Contributions:
Comment about this article or add new information about this topic: