Human genomic deletions mediated by recombination between Alu elements
Article Abstract:
The reference human and chimpanzee genomes are compared to determine the magnitude of the recombination between Alu elements in the human lineage since the human-chimpanzee divergence ~6 million years ago. It is found that Alu recombination-mediated genomic deletion has had a much higher impact than was inferred from previously identified isolated events and that it continues to contribute to the dynamic nature of the human genome.
author: Cordaux, Richard, Batzer, Mark A., Hui Wang, Dyer, Matthew, Sen, Shurjo, K., Kyudong Han, Jianxin Wang, Jungnam Lee, Callinan, Pauline A., Ping Liang
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
Louisiana, Genetic aspects, Human beings, Humans, Chimpanzees, Man, Quantitative trait loci
Characterization of apparently balanced chromosomal rearrangements from the Developmental Genome Anatomy Project
Article Abstract:
The Developmental Genome Anatomy Project (DGAP) aims at identifying and characterizing the different genes related to the apparently balanced chromosomal rearrangements in human bodies. These rearrangements are found to be extremely beneficial in studying the gene discovery and annotation.
author: Harris, David J., Bruns, Gail A.P., Gusella, James F., Morton, Cynthia C., Leach, Natalia T., Korf, Bruce R., Quade, Bradley J., Maas, Richard L., Kulkarni, Shashikant, Hyung-Goo Kim, Yanli Fan, Ligon, Azra H., Kishikawa, Shotaro, Higgins, Anne W., Donovan, Diana J., Lally, Eric, Alkuraya, Fowzan S., Bosco, Amy F., Brown, Kerry K., Eisenman, Robert, Farra, Chantal G., Ferguson, Heather L., Herrick, Steven R., Kelly, Chantal, Lemyre, Emma, Lewis, Janine, Moore, Steven D.P., Peters, Roxanna E., Quintero-Rivera, Fabiola, Saadi, Irfan, Shendure, Jay, Williamson, Robin E.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2008
Chromosome replication, Human anatomy
DNA methylation signatures within the human brain
Article Abstract:
Brain samples from individuals are analyzed and quantitative to determine the DNA methylation levels representing genes with diverse functions. The DNA methylation signatures distinguish brain regions and help account for region-specific functional programs.
author: Feinberg, Andrew P., Pevsner, Jonathan, Callinan, Pauline A., Ladd-Acosta, Christine, Sabunciyan, Sarven, Yolken, Robert H., Webster, Maree J., Dinkins, Tiffany, Fan, Jian-Bing, Potash, James B.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
Biological Product (except Diagnostic) Manufacturing, Drugs, Deoxyribonucleic Acid, DNA, Brain research, Gene expression, Methylation, Chemical properties, Human genome
subjects list: Research, Analysis, Polymerase chain reaction, Genomes
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