Human and mouse homologs of Schizosaccharomyces pombe rad1+ and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis

Article Abstract:

Mouse and human homologs of the Schizosaccharomyces pombe DNA damage checkpoint control gene rad1+ and the Saccharomyces cerevisiae homolog RAD17 have been identified. A link to meiosis in mammals and to checkpoint controlexists and its seems the yeast events are highly conserved in humans. HRAD1 is on chromosome 5p13 and is most homologous to S. pombe rad1+.

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The yeast Xrs2 complex functions in S phase checkpoint regulation

Article Abstract:

The Saccharomyces cerevisiae Xrs2 complex has been found to have a role in S phase checkpoint regulation and DNA damage brings phosphorylation of Srs2p and Mre11p in a Tel1p-dependent way. Study showed that the Tel1p/ATM signaling pathway is conserved from yeast to humans. It appears that the Srs2p/Nbs1 complexes act as signal modifiers.

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Functional links between telomeres and proteins of the DNA-damage response

Article Abstract:

The role of DNA-damage response (DDR) factors in regulating telomere length and stability, and explanation of the way dysfunctional telomere triggers the DDR is described. The salient features of both telomeres and the DDR are presented.

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