Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans

Article Abstract:

Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans.

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PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans

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PIE-1 has been found to be a bifunctional protein regulating maternal/zygotic gene expression in the Caenorhabditis elegans embryonic germ line. It promotes germ cell fate by two mechanisms independent of one another.

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Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

Article Abstract:

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase has been found to associate with components of the mRNA surveillance complex. It is involved in the regulation of nonsense-mediated mRNA decay (NMD) and is a human ortholog of a product of Caenorhabditis elegans smg-1, which is one of its smg genes involved in NMD. A critical role in NMD is played by hSMG-1 through direct phosphorylation of hUPF1/SMG-2.

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