Hox genes specify vertebral types in the presomitic mesoderm

Article Abstract:

Expression of Hoxa10 in the presomitic mesoderm is sufficient to confer a Hox group 10 patterning program to the somite, producing vertebrae without ribs, an effect not achieved when Hoxa10 is expressed in the somites. Hox group 11-dependent vertebral sacralization requires Hoxa11 expression in the presomitic mesoderm, while their caudal differentiation requires that Hoxa11 is expressed in the somites.

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A core transcriptional network for early mesoderm development in Drosophila melanogaster

Article Abstract:

The characteristics of the regulatory network orchestrating early mesodermal development which require the transcription factor twist as necessary factor to drive development is reported. The results suggest that twist binds to almost all mesodermal cis-regulatory modules (CRMs) to provide the competence to integrate inputs from more specialized transcription factors.

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The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response

Article Abstract:

A study shows that HDAC6 is a central component of the stress response regulating SG formation and potentially contributing to the control of RNA metabolism and translation.

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